Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 19 0.0 0.701 0.228 0.236
biological_process el 19 0.078 0.96 0.616 0.298
biological_process ka 19 0.0 0.682 0.218 0.247
biological_process rf 19 0.0 0.701 0.228 0.236
cellular_component ct 20 0.001 0.917 0.295 0.25
cellular_component el 20 0.053 0.928 0.474 0.315
cellular_component ka 20 0.002 0.966 0.3 0.258
cellular_component rf 20 0.001 0.917 0.295 0.25
disease ct 12 0.002 0.945 0.139 0.299
disease el 12 0.014 0.829 0.603 0.268
disease ka 12 0.001 0.937 0.14 0.304
disease rf 12 0.002 0.935 0.138 0.296
genetic_interaction ct 16 0.025 0.95 0.524 0.287
genetic_interaction el 16 0.027 1.0 0.549 0.265
genetic_interaction ka 16 1.0 1.0 1.0 0.0
genetic_interaction rf 16 0.025 1.0 0.554 0.297
molecular_function ct 20 0.0 0.951 0.43 0.302
molecular_function el 20 0.126 0.968 0.479 0.25
molecular_function ka 20 0.0 0.943 0.435 0.306
molecular_function rf 20 0.0 0.951 0.427 0.302
pathway ct 4 0.056 0.202 0.132 0.054
pathway el 4 0.002 0.151 0.087 0.057
pathway ka 4 0.002 1.0 0.533 0.469
pathway rf 4 0.038 0.157 0.093 0.045
phenotype ct 12 0.001 0.347 0.081 0.118
phenotype el 12 0.273 0.976 0.662 0.239
phenotype ka 12 0.001 0.441 0.088 0.132
phenotype rf 12 0.001 0.347 0.081 0.118
protein_interaction ct 20 0.0 0.668 0.076 0.162
protein_interaction el 20 0.0 0.715 0.073 0.171
protein_interaction ka 20 0.002 1.0 0.701 0.457
protein_interaction rf 20 0.0 0.659 0.074 0.159

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 20 0.0 0.853 0.351 0.287
integration_mean_by_presence el 20 0.01 0.893 0.4 0.264
integration_mean_by_presence ka 20 0.0 0.724 0.131 0.181
integration_mean_by_presence rf 20 0.001 0.352 0.042 0.079
mean ct 20 0.0 0.828 0.3 0.302
mean el 20 0.002 0.821 0.266 0.223
mean ka 20 0.0 0.345 0.079 0.115
mean rf 20 0.0 0.349 0.047 0.085

CDF plots of non integrated kernels

CDF plots of integrated kernels